Mechanisims of asthma and allergic disease – 1064. Interleukin 31 (IL 31) serum levels in atopic dermatitis patients
نویسندگان
چکیده
Background Atopic dermatitis is a common chronic skin disorder which is a subset of atopy. Atopy refers to a genetic predisposition to respond immunonologically to allergens which are generally harmless, causingover production of immunoglobulin E (IgE) antibodies. IgE synthesis is dependent on the activation of CD4+ Th2 subset and their secretion of cytokines including IL 4 and IL 13. This study was done to compare between IL 31 serum levels in normal controls and atopic dermatitis patients in Kelantan, Malaysia.
منابع مشابه
Association of LL-37 and IL-31 serum levels with SCORing Atopic Dermatitis (SCORAD) score in atopic dermatitis patients
Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited i...
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Methods This was a comparative cross sectional study. Cases were patients having allergic diseases such as atopic dermatitis (AD) attending the skin clinic of Hospital Universiti Sains Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ II), Malaysia, allergic rhinitis (AR) attending ENT clinic in HUSM and atopic asthma (AA) attending chest clinic and pediatric clinic in HUSM. The patie...
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BACKGROUND Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the novel cytokine IL-31 has been implicated in the itching associated with AD. OBJECTIVE We performed this study to determine whether IL-31 serum levels are elevated in AD patients and to better characterize the relationship between serum IL-31 level and other established laboratory parameters. METHODS W...
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BACKGROUND Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma. METHODS Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (...
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Background & Aims: Atopic dermatitis is a common allergic disease recognized as a threat to public health. Atopic dermatitis is often observed in people with individual or family history of allergic diseases. Due to the importance of this disease and its early diagnosis, and the very limited number of studies on this topic, the current study was performed on the prevalence of atopic dermatitis ...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2013